Perhalogenated pyrimidine scaffolds. Reactions of 5-chloro- 2,4,6-trifluoropyrimidine with nitrogen centred nucleophiles

• Emma L. Parks,
• Graham Sandford,
• John A. Christopher and
• David D. Miller

Beilstein J. Org. Chem. 2008, 4, No. 22, doi:10.3762/bjoc.4.22

• derivatives can be isolated in acceptable yields using this methodology. Keywords: pyrimidine; rapid analogue synthesis; perfluoroheteroaromatic; nucleophilic aromatic substitution; Introduction Highly functionalised pyrimidine derivatives are of great importance to the life-science industries and, indeed

• these reactions are not regiospecific and, furthermore, there is an added difficulty of synthesizing a range of structurally related pyrimidine analogues by parallel synthesis or rapid analogue synthesis (RAS) techniques [6][7] due to the limited range of non-cyclic polyfunctional precursors available